While some medications are designed for rectal administration, most are not. The solution is then injected into the anus via an oral or needleless syringe. Opiates, or other drugs, are usually crushed into powder and mixed with water to created a drug-infused solution. “Plugging” is another name for rectal administration, or inserting drugs into the anus. The Dangers Of “Plugging” Prescription Opiates This route of administration can be dangerous because it bypasses the body’s natural defenses against overdose. Plugging is commonly associated with drug misuse, which means the person may suffer from a substance use disorder (SUD).
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